abstract：BACKGROUND:Genetic studies of single gene variants have been criticized as providing a simplistic characterization of the genetic basis of illness risk that ignores the effects of other variants within the same biological pathways. Of candidate biological pathways for schizophrenia (SZ), the cell adhesion molecule (CAM...

journal_title：Psychological medicine

authors： Hargreaves A,Anney R,O'Dushlaine C,Nicodemus KK,Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ).,Wellcome Trust Case Control Consortium 2.,Gill M,Corvin A,Morris D,Donohoe G

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Affective instability (AI) is poorly defined but considered clinically important. The aim of this study was to examine definitions and measures of AI employed in clinical populations. METHOD:This study was a systematic review using the PRISMA guidelines. MEDLINE, Embase, PsycINFO, PsycArticles and Web of Sc...

journal_title：Psychological medicine

authors： Marwaha S,He Z,Broome M,Singh SP,Scott J,Eyden J,Wolke D

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The neurocognitive deficits and other correlates of problem gambling are also observable in individuals with lower cognitive abilities, suggesting that a low IQ may be a determinant of problem gambling. There has been very little research into this possibility. This study aimed to investigate the characteris...

journal_title：Psychological medicine

authors： Rai D,Hall W,Bebbington P,Skapinakis P,Hassiotis A,Weich S,Meltzer H,Moran P,Brugha T,Strydom A,Farrell M

更新日期：2014-06-01 00:00:00

abstract：:The examination of moment-to-moment, 'micro-level' patterns of experience and behaviour using experience sampling methodology has contributed to our understanding of the 'macro-level' development of full-blown symptoms and disorders. This paper argues that the micro-level perspective can be used to identify the smalle...

journal_title：Psychological medicine

authors： Wichers M

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Aberrant functional connectivity within the default network is generally assumed to be involved in the pathophysiology of obsessive compulsive disorder (OCD); however, the genetic risk of default network connectivity in OCD remains largely unknown. METHOD:Here, we systematically investigated default network...

journal_title：Psychological medicine

authors： Peng ZW,Xu T,He QH,Shi CZ,Wei Z,Miao GD,Jing J,Lim KO,Zuo XN,Chan RC

更新日期：2014-05-01 00:00:00

abstract：BACKGROUND:Attention deficit hyperactivity disorder (ADHD) often, but not always, persists into adulthood. Investigations of the associations between clinical and biological markers of persistence can shed light on causal pathways. It has been proposed that compensatory improvements in executive neuropsychological func...

journal_title：Psychological medicine

authors： Coghill DR,Hayward D,Rhodes SM,Grimmer C,Matthews K

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Although impaired recognition of affective facial expressions has been conclusively linked to antisocial behavior, little is known about the modifiability of this deficit. This study investigated whether and under which circumstances the proposed perceptual insensitivity can be addressed with a brief implici...

journal_title：Psychological medicine

authors： Schönenberg M,Christian S,Gaußer AK,Mayer SV,Hautzinger M,Jusyte A

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:There is substantial variability in the degree of cognitive impairment among older depressed persons. Inconsistencies in previous findings may be due to differences in clinical and demographic characteristics across study samples. We assessed the influence of unipolar depression and severity of depression on...

journal_title：Psychological medicine

authors： Pantzar A,Laukka EJ,Atti AR,Fastbom J,Fratiglioni L,Bäckman L

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Pre- and perinatal adversities may increase the risk for schizophrenia and bipolar disorder. Hypoxia-related obstetric complications (OCs) are associated with brain anatomical abnormalities in schizophrenia, but their association with brain anatomy variation in bipolar disorder is unknown. METHOD:Magnetic r...

journal_title：Psychological medicine

authors： Haukvik UK,McNeil T,Lange EH,Melle I,Dale AM,Andreassen OA,Agartz I

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:This study examined two competing hypotheses concerning the association between diabetes and treatment for depression: (1) the detection/ascertainment bias hypothesis suggesting that those with diabetes are more likely to be diagnosed with and treated for depression because of increased medical attention and...

journal_title：Psychological medicine

authors： Manderbacka K,Jokela M,Sund R,Elovainio M

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:The World Mental Health Survey Initiative (WMHSI) has advanced our understanding of mental disorders by providing data suitable for analysis across many countries. However, these data have not yet been fully explored from a cross-national lifespan perspective. In particular, there is a shortage of research o...

journal_title：Psychological medicine

authors： McDowell RD,Ryan A,Bunting BP,O'Neill SM,Alonso J,Bruffaerts R,de Graaf R,Florescu S,Vilagut G,de Almeida JM,de Girolamo G,Haro JM,Hinkov H,Kovess-Masfety V,Matschinger H,Tomov T

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:The effects of antidepressants for treating depressive disorders have been overestimated because of selective publication of positive trials. Reanalyses that include unpublished trials have yielded reduced effect sizes. This in turn has led to claims that antidepressants have clinically insignificant advanta...

journal_title：Psychological medicine

authors： Cuijpers P,Turner EH,Mohr DC,Hofmann SG,Andersson G,Berking M,Coyne J

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Structural models of emotional disorders propose that anxiety disorders can be classified into fear and distress disorders. Sources of evidence for this distinction come from genetic, self-report and neurophysiological data from adults. The present study examined whether this distinction relates to cognitive...

journal_title：Psychological medicine

authors： Waters AM,Bradley BP,Mogg K

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The past two decades have seen exponential clinical and research interest in help-seeking individuals presenting with potentially prodromal symptoms for psychosis. However, the epidemiological validity of this paradigm has been neglected, limiting future advancements in the field. METHOD:We undertook a crit...

journal_title：Psychological medicine

authors： Fusar-Poli P,Yung AR,McGorry P,van Os J

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:There are no evidence-based treatments for severe and enduring anorexia nervosa (SE-AN). This study evaluated the relative efficacy of cognitive behavioral therapy (CBT-AN) and specialist supportive clinical management (SSCM) for adults with SE-AN. METHOD:Sixty-three participants with a diagnosis of AN, who...

journal_title：Psychological medicine

authors： Touyz S,Le Grange D,Lacey H,Hay P,Smith R,Maguire S,Bamford B,Pike KM,Crosby RD

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Previous studies suggest a link between parental separation or divorce and risk of depression in adolescence. There are, however, few studies that have prospectively examined the effects of timing of biological father absence on risk for depressive symptoms in adolescence while controlling for a range of con...

journal_title：Psychological medicine

authors： Culpin I,Heron J,Araya R,Melotti R,Joinson C

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Previous studies support Beck's cognitive model of vulnerability to depression. However, the relationship between his cognitive triad and other clinical features and risk factors among those with major depression (MD) has rarely been systematically studied. METHOD:The three key cognitive symptoms of worthle...

journal_title：Psychological medicine

authors： Wang L,Liu L,Shi S,Gao J,Liu Y,Li Y,Zhang Z,Wang G,Zhang K,Tao M,Gao C,Li K,Wang X,Lv L,Jiang G,Wang X,Jia H,Zhang J,Lu C,Li Y,Li K,Hu C,Ning Y,Li Y,Sun J,Liu T,Zhang Y,Ha B,Tian H,Meng H,Hu J

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Several psychological and neurobiological models imply that patients with schizophrenia (SCZ) are more inclined to utilize emotional cues as response determinants to the detriment of more task-appropriate cognitive or contextual cues. However, there is a lack of behavioural data from human clinical studies t...

journal_title：Psychological medicine

authors： Patrick RE,Christensen BK

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:A multi-centre, four-arm trial (the PACE trial) found that rehabilitative cognitive behaviour therapy (CBT) and graded exercise therapy (GET) were more effective treatments for chronic fatigue syndrome (CFS) than specialist medical care (SMC) alone, when each was added to SMC, and more effective than adaptiv...

journal_title：Psychological medicine

authors： White PD,Goldsmith K,Johnson AL,Chalder T,Sharpe M

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Although depression and mania are often assumed to be polar opposites, studies have shown that, in patients with bipolar disorder, they are weakly positively correlated and vary somewhat independently over time. Thus, when investigating relationships between specific psychological processes and specific symp...

journal_title：Psychological medicine

authors： Pavlickova H,Varese F,Turnbull O,Scott J,Morriss R,Kinderman P,Paykel E,Bentall RP

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Risk factors that are associated with depression in the mother also negatively affect the child. This research sought to extend current knowledge by examining the duration and timing of maternal depression as a moderator of: (1) the impact of dependent interpersonal stress (DIS), such as partner conflict or ...

journal_title：Psychological medicine

authors： Barker ED

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:In previous studies an association between deployment to Iraq or Afghanistan and an overall increased risk for post-traumatic stress disorder (PTSD) in UK armed forces has not been found. The lack of a deployment effect might be explained by including, in the comparison group, personnel deployed on other ope...

journal_title：Psychological medicine

authors： Jones M,Sundin J,Goodwin L,Hull L,Fear NT,Wessely S,Rona RJ

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Whether late-onset depression is a risk factor for or a prodrome of dementia remains unclear. We investigated the impact of depressive symptoms and early- v. late-onset depression on subsequent dementia in a cohort of elderly general-practitioner patients (n = 2663, mean age = 81.2 years). METHOD:Risk for s...

journal_title：Psychological medicine

authors： Heser K,Tebarth F,Wiese B,Eisele M,Bickel H,Köhler M,Mösch E,Weyerer S,Werle J,König HH,Leicht H,Pentzek M,Fuchs A,Riedel-Heller SG,Luppa M,Prokein J,Scherer M,Maier W,Wagner M,Age CoDe Study Group.

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:Moodscope is an entirely service-user-developed online mood-tracking and feedback tool with built-in social support, designed to stabilize and improve mood. Many free internet tools are available with no assessment of acceptability, validity or usefulness. This study provides an exemplar for future assessmen...

journal_title：Psychological medicine

authors： Drake G,Csipke E,Wykes T

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Anxiety disorders are very common and increase risk for suicide attempts. Little is known about predictors of increased risk specifically among individuals with anxiety disorders. The purpose of this study was to investigate whether specific anxiety disorders and other co-morbid psychiatric disorders, physic...

journal_title：Psychological medicine

authors： Uebelacker LA,Weisberg R,Millman M,Yen S,Keller M

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:This study aimed to determine whether depression in patients with long-term conditions is associated with the number of morbidities or the type of co-morbidity. Method A cohort study of 299 912 participants aged 30-100 years. The prevalence of depression, rates of health-care utilization and costs were evalu...

journal_title：Psychological medicine

authors： Bhattarai N,Charlton J,Rudisill C,Gulliford MC

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Psychological traumatic events, such as war or road traffic accidents, are widespread. A small but significant proportion of survivors develop post-traumatic stress disorder (PTSD). Distressing, sensory-based involuntary memories of trauma (henceforth 'flashbacks') are the hallmark symptom of PTSD. Understan...

journal_title：Psychological medicine

authors： Bourne C,Mackay CE,Holmes EA

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The mechanisms that contribute to emotion dysregulation in anxiety disorders are not well understood. Two common disorders, generalized anxiety disorder (GAD) and panic disorder (PD), were examined to test the hypothesis that both disorders are characterized by hypo-activation in prefrontal cortex (PFC) duri...

journal_title：Psychological medicine

authors： Ball TM,Ramsawh HJ,Campbell-Sills L,Paulus MP,Stein MB

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Cognitive remediation (CR) is an effective treatment for several psychiatric disorders. To date, there have been no published studies examining solely first-episode psychiatric cohorts, despite the merits demonstrated by early intervention CR studies. The current study aimed to assess the effectiveness of CR...

journal_title：Psychological medicine

authors： Lee RS,Redoblado-Hodge MA,Naismith SL,Hermens DF,Porter MA,Hickie IB

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Studies investigating early developmental factors in relation to psychopathology have mainly focused on schizophrenia. The personality dimension of neuroticism seems to be a general risk factor for psychopathology, but evidence on associations between early developmental precursors and personality traits is ...

journal_title：Psychological medicine

authors： Flensborg-Madsen T,Sørensen HJ,Revsbech R,Mortensen EL

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Although many studies have addressed the topic of stability versus change in depressive symptoms, few have further decomposed the change to continuous accumulation versus non-systematic state fluctuations or measurement errors. This further step requires a longitudinal follow-up and an appropriate stochastic...

journal_title：Psychological medicine

authors： Rosenström T,Jokela M,Hintsanen M,Pulkki-Råback L,Hutri-Kähönen N,Keltikangas-Järvinen L

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Research suggests that the personality factor of self-critical or maladaptive perfectionism may be implicated in chronic fatigue syndrome (CFS). However, it is not clear whether self-critical perfectionism (SCP) also predicts daily symptoms in CFS. Method In the present study we investigated whether SCP pred...

journal_title：Psychological medicine

authors： Kempke S,Luyten P,Claes S,Goossens L,Bekaert P,Van Wambeke P,Van Houdenhove B

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Assortative mating has been demonstrated in mental disorders but the extent of cohabitation between patients with clinically diagnosed psychiatric disease has been poorly explored. Method We conducted a register-based study of all Danes between 18 and 70 years of age in a 13-year observational period, linkin...

journal_title：Psychological medicine

authors： Thomsen AF,Olsbjerg M,Andersen PK,Kessing LV

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Prior studies have suggested that major depressive disorder (MDD) with pre-adult onset represents a distinct subtype with greater symptom severity and higher rates of suicidal ideation. Whether these patients have poorer response to various types of antidepressant treatment than those with adult-onset MDD is...

journal_title：Psychological medicine

authors： Sung SC,Wisniewski SR,Balasubramani GK,Zisook S,Kurian B,Warden D,Trivedi MH,Rush AJ,CO-MED Study Team.

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Individual variation in the clinical course of bipolar disorder may have prognostic and therapeutic implications but is poorly reflected in current classifications. We aimed to establish a typology of the individual clinical trajectories based on detailed prospective medium-term follow-up. Method Latent clas...

journal_title：Psychological medicine

authors： Uher R,Mantere O,Suominen K,Isometsä E

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND:Executive dysfunction, distinct from other cognitive deficits in depression, has been associated with suicidal behavior. However, this dysfunction is not found consistently across samples. METHOD:Medication-free subjects with DSM-IV major depressive episode (major depressive disorder and bipolar type I diso...

journal_title：Psychological medicine

authors： Keilp JG,Gorlyn M,Russell M,Oquendo MA,Burke AK,Harkavy-Friedman J,Mann JJ

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Although numerous studies have examined the latent structure of major depression, less attention has focused on mania. This paper presents the first investigation outside the USA to evaluate the psychometric properties of the DSM-IV criterion B mania symptoms using item response theory (IRT). METHOD:Data we...

journal_title：Psychological medicine

authors： Carragher N,Weinstock LM,Strong D

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Social anxiety disorder (SAD) is surprisingly prevalent among people with psychosis and exerts significant impact on social disability. The processes that underlie its development remain unclear. The aim of this study was to investigate the relationship between shame cognitions arising from a stigmatizing ps...

journal_title：Psychological medicine

authors： Michail M,Birchwood M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Stress questionnaires are included in many epidemiological cohort studies but the psychometric characteristics of these questionnaires are largely unknown. The aim of this study was to describe these characteristics for two short questionnaires measuring the lifetime and past year occurrence of stress: the L...

journal_title：Psychological medicine

authors： Rosmalen JG,Bos EH,de Jonge P

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The relationship between recurrent major depression (MD) in women and suicidality is complex. We investigated the extent to which patients who suffered with various forms of suicidal symptomatology can be distinguished from those subjects without such symptoms. METHOD:We examined the clinical features of th...

journal_title：Psychological medicine

authors： Bi B,Xiao X,Zhang H,Gao J,Tao M,Niu H,Wang Y,Wang Q,Chen C,Sun N,Li K,Fu J,Gan Z,Sang W,Zhang G,Yang L,Tian T,Li Q,Yang Q,Sun L,Li Y,Rong H,Guan C,Zhao X,Ye D,Zhang Y,Ma Z,Li H,He K,Chen J,Cai

更新日期：2012-12-01 00:00:00